The Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy marked by flaccid areflexic paralysis.Although the pathogenesis of GBS remains incompletely defined, considered as an autoimmune disease most frequentlytriggered by an previous infection. Antecedent infections with Campylobacter jejuni, cytomegalovirus, Ebstein-Barrvirus, Mycoplasma pneumoniae, Haemophilus influenzae, human immunodeficiency virus, enterovirus, rotavirus arecommon. But, it is rare that GBS following typhoid fever. We present a case of typical GBS after antecedentSalmonella typhi infection.